Introduction Understanding the dynamics of T-cell receptor (TCR) and B-cell receptor (BCR) clonotypes is essential for advancing our knowledge of immune system functionality and its role in health and disease. Single-cell RNA sequencing (scRNAseq) combined with TCR/BCR sequencing provides a robust framework for analyzing clonotype diversity and repertoire structure
Introduction Recent advances in single-cell RNA sequencing (scRNAseq) technologies have revolutionized the study of cellular heterogeneity, characteristics, and activity in various environments. Yet accurate, reproducible, harmonized, consistent, and automated cell type annotation remains a significant challenge. In this blog post, we will explore some of the major approaches of automated
Introduction Unlocking the molecular mechanisms of Alzheimer's disease involves exploring both genetic and epigenetic factors that contribute to cellular dysfunction. Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) is a powerful technique that provides insights into chromatin accessibility at the single-cell level, shedding light on gene regulation and
In the ever-changing world of biological research, understanding how cells communicate within their spatial context is crucial. The 10X Visium HD technology has become a game-changer, allowing scientists to study cell interactions with amazing detail and clarity. In this post, we explore the capabilities of the Visium HD dataset to
Uncovering hidden treasures in cellular diversity The advent of single-cell technologies has revolutionized our understanding of biological complexity, providing a lens through which we can discern the fine details of cellular heterogeneity. This transformative approach enables researchers to characterize cell types and discover new subtypes that have remained elusive with