TCR/BCR
Unveiling clonotype diversity and repertoire overlap in diseased PBMCs through OmnibusX analysis
Introduction Understanding the dynamics of T-cell receptor (TCR) and B-cell receptor (BCR) clonotypes is essential for advancing our knowledge of immune system functionality and its role in health and disease. Single-cell RNA sequencing (scRNAseq) combined with TCR/BCR sequencing provides a robust framework for analyzing clonotype diversity and repertoire structure